Interobserver Variability in Scoring Percentages of Tumor-Infiltrating Lymphocytes in Breast Core Needle Biopsies
نویسندگان
چکیده
منابع مشابه
Tumor-infiltrating lymphocytes in breast cancer
We have prospectively validated in an independent clinical cohort the finding that elevated amounts of tumor-infiltrating lymphocytes in breast carcinoma tissues predict the response of patients to neoadjuvant chemotherapy. These results suggest that a robust tumor infiltration by T and B cells is a promising biomarker to define patients who might benefit from neoadjuvant chemotherapy.
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Angiogenesis, the formation of new blood vessels from a preexisting vascular bed, is a complex multistep process. To investigate how tumor angiogenesis correlates with tumor grading in breast carcinoma diagnosed on core biopsy, microvessels were counted (and graded the density of microvessels) within the initial invasive carcinomas of 158 patients. Using light microscopy, the number of microves...
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While breast cancer has not been considered a cancer amenable to immunotherapeutic approaches, recent studies have demonstrated evidence of significant immune cell infiltration via tumor-infiltrating lymphocytes in a subset of patient tumors. In this review we present the current evidence highlighting the clinical relevance and utility of tumor-infiltrating lymphocytes in breast cancer. Retrosp...
متن کاملCharacterization and quantification of tumor infiltrating lymphocytes in breast cancer
Results A positive correlation between CD3 and CD8 expression (rs=0.614, n=24, P 0.001) and CD3 and CD45RO expression (rs=0.621, n=24, P 0.001) were noted in the center of the tumor (CT).CD3 median percentage in CT was higher in grade 2 and grade 3 breast carcinoma compared to grade 1 (P 0.023). CD3 in the center of the tumor and CD8 in the invasive margins (IM) were significantly higher in ER/...
متن کاملClinical significance of tumor-infiltrating lymphocytes in breast cancer
Tumor infiltrating lymphocytes (TIL) play an essential role in mediating response to chemotherapy and improving clinical outcomes in all subtypes of breast cancer. Triple negative breast cancers (TN) are most likely to have tumors with >50 % lymphocytic infiltrate, termed lymphocyte predominant breast cancer, and derive the greatest survival benefit from each 10 % increase in TIL. The majority ...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2018
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/aqy090.068